Citation on PubMed or Free article on PubMed Central Levels of HDL cholesterol and atherosclerosis, a variable relationship-a review Savel J, Lafitte M, Pucheu Y, Pradeau V, Tabarin A, Couffinhal T.Structuralĭifferences between wild-type and fish eye disease mutant of lecithin:cholesterolĪcyltransferase. Reshetnyak Y, Tchedre KT, Nair MP, Pritchard PH, Lacko AG. Two novel molecular defects in the LCAT gene are associated withįish eye disease. Kuivenhoven JA, Stalenhoef AF, Hill JS, Demacker PN, Errami A, Kastelein JJ,.The lecithin: cholesterol acyltransferase (LCAT) gene associated with fish eyeĭisease. Contacos C, Sullivan DR, Rye KA, Funke H, Assmann G.Syndromes: a comprehensive study of molecular and biochemical findings in 13 The molecular basis of lecithin:cholesterol acyltransferase deficiency T, Sessa A, Vaudo G, Cantafora A, Veglia F, Calandra S, Bertolini S, Franceschini Lupattelli G, Montali A, Pizzolitto S, Rabbone I, Rolleri M, Ruotolo G, Sampietro Calabresi L, Pisciotta L, Costantin A, Frigerio I, Eberini I, Alessandrini P,Īrca M, Bon GB, Boscutti G, Busnach G, Frascà G, Gesualdo L, Gigante M,.Mutations that affect both alpha-LCAT activity and beta-LCAT activity lead to a related disorder called complete LCAT deficiency, which involves corneal opacities in combination with features affecting other parts of the body. It is not known why the cholesterol deposits affect only the corneas in this disorder. Impairment of this mechanism for reducing cholesterol in the body leads to cholesterol-containing opacities in the corneas. LCAT gene mutations that cause fish-eye disease impair alpha-LCAT activity, reducing the enzyme's ability to attach cholesterol to HDL. Beta-LCAT activity helps attach cholesterol to other lipoproteins called very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL). Alpha-LCAT activity helps attach cholesterol to a lipoprotein called high-density lipoprotein (HDL). The enzyme has two major functions, called alpha- and beta-LCAT activity. Once in the liver, the cholesterol is redistributed to other tissues or removed from the body. The LCAT enzyme plays a role in removing cholesterol from the blood and tissues by helping it attach to molecules called lipoproteins, which carry it to the liver. This gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT). They can pop up on the tip of the penis, around the anus, or on the scrotum, thigh, or groin.Fish-eye disease is caused by mutations in the LCAT gene. Genital warts can appear near the vaginal or cervical areas, on the vulva, inside the vagina, or around the anus. Genital warts: Also called condylomata acuminata, genital warts appear flesh-colored and flat or bumpy (like cauliflower).They often grow quickly and show up on the face, generally around the eyes, mouth, and nose. Filiform warts: Filiform warts have a base where strands look like threads sticking out.Adults may likely get them under their beards and find them on their legs. Children usually develop flat warts on their faces. Flat warts: Flat warts tend to be smaller and smoother than other types but may grow in large numbers (anywhere from 20 to 100).They can also grow in clusters and have seeds in the middle. Plantar warts: Typically growing on the sole, or the plantar surface, of feet, plantar warts may be painful.They are most common among children and can present as rough bumps, sometimes with black dots, or "seeds," in the middle. Common warts: Also known as verruca vulgaris, common warts typically grow on the fingers, near the nails, or on the backs of the hands.
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